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Study identifier: NCT07088952 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle

Condition: Embryo Transfer  ·  Sponsor: Vida Recoletas Sevilla

PhaseNA
Planned participants572
Who can joinFemale, 18 Years to 50 Years
Healthy volunteersNo

About this study

The rise in frozen embryo transfer (FET) cycles within assisted reproductive technology (ART) has sparked the need to refine endometrial preparation protocols. The switch from hormone replacement cycles (HRT) to natural cycles, poses scheduling challenges onto laboratories, doctors and patients. The modified natural cycle (mNC), offering more precision for scheduling, shows promise but lacks comprehensive data on the potential flexibility of triggering criteria that may allow to control timing in a wider range. This prospective randomized study seeks to address this knowledge gap by evaluating the non-inferiority of triggering ovulation in mNC with follicle diameters of 13-16.9mm compared to the conventional 17-22mm. The study aims to enhance the understanding of the impact of follicle size at ovulation in reproductive outcomes, optimize FET treatments providing a more flexible mNC protocol, and improve patient care in ART clinics.

This description comes directly from the study's public registry record.

Talk to the study team

Manuel Fernández Sánchez, MD PhD  ·  +34954286274  ·  vida.investiga@gruporecoletas.com

Clara Palacio de Marco, MSc  ·  +34954286274  ·  clara.palacio@gruporecoletas.com

Always discuss trial participation with your own doctor first.

Locations (1)

Vida Recoletas SevillaSeville, Sevilla, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT07088952