Condition: Dementia, Mild · Mild Cognitive Impairment · Type 2 Diabetes · Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
The LIGHT-COG study is a 76-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial. A total of 420 type 2 diabetes patients with early dementia are randomized 1:1 to either the active treatment group (receiving subcutaneous injections of mazdutide weekly, with stepwise dose escalation to a maintenance dose per protocol) or the placebo group (receiving matched placebo injections). The primary objective is to evaluate the potential disease-modifying effects of mazdutide on cognitive dysfunction in type 2 diabetes.
This description comes directly from the study's public registry record.
Yan Bi, MD, PhD · 6-25-83-105302. · biyan@nju.edu.cn
Zhou Zhang, MD, PhD · 86-25-83-105302 · zhangzhou@smail.nju.edu.cn
Always discuss trial participation with your own doctor first.
| Department of Endocrinology, Xiangya Hospital of Central South University | Changsha, Hunan, China | Not Yet Recruiting |
| Department of Endocrinology, Changzhou No.2 People's Hospital | Changzhou, Jiangsu, China | Recruiting |
| Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University | Nanjing, Jiangsu, China | Recruiting |
| Department of Endocrinology, Endocrine and Metabolic Disease Medical Center,Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University | Nanjing, Jiangsu, China | Recruiting |
| Department of Endocrinology, Jiangsu Province Hospital of Traditional Chinese Medicine | Nanjing, Jiangsu, China | Recruiting |
| The Second Affiliated Hospital of Dalian Medical University | Dalian, Liaoning, China | Not Yet Recruiting |
| Department of Endocrinology, Shanghai General Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
| Department of Endocrinology, Huadong Hospital Affiliated to Fudan University | Shanghai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07083154