● Recruiting

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

Condition: Metastatic Colorectal Cancer · Sponsor: BioNTech SE

PhasePhase 1/Phase 2

Planned participants482

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

This randomized, multi-site, three-part study will test a new treatment called BNT314, which is designed to help the body's own defense to fight cancer in combination with another new treatment (pumitamig, which is a cancer immunotherapy drug also known as BNT327 and PM8002) and chemotherapy in participants with metastatic colorectal cancer (mCRC).

This description comes directly from the study's public registry record.

Talk to the study team

BioNTech clinical trials patient information · +49 6131 9084 · patients@biontech.de

Always discuss trial participation with your own doctor first.

Locations (14)

Yale University	New Haven, Connecticut, United States	Recruiting
START Midwest	Grand Rapids, Michigan, United States	Recruiting
Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center	Cleveland, Ohio, United States	Recruiting
The University of Texas MD Anderson Cancer Center	Houston, Texas, United States	Recruiting
Hämatologisch-Onkologische Praxis Eppendorf - HOPE	Hamburg, Germany	Recruiting
Asklepios Tumorzentrum Hamburg	Hamburg, Germany	Recruiting
National Cancer Center Hospital	Chūōku, Japan	Recruiting
National Cancer Center Hospital East	Kashiwa, Japan	Recruiting
Hospital HM Nou Delfos	Barcelona, Spain	Recruiting
Vall D'Hebrón Hospital	Barcelona, Spain	Recruiting
Centro Integral Oncologico Clara Campal	Madrid, Spain	Recruiting
Guy's & St Thomas' NHS Foundation Trust, Guy's Hospital	London, United Kingdom	Recruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07079631