Condition: Hepatitis B, Chronic (CHB) · Hepatitis B · Hepatitis B Virus (HBV) · Sponsor: First Affiliated Hospital Xi'an Jiaotong University
Chronic hepatitis B can develop into cirrhosis and liver cancer, which seriously endangers the life and health of people. In China, HBV is mainly transmitted from mother to child, showing the phenomenon of family clusters. Similarly, cirrhosis and hepatocellular carcinoma occur in familial clusters. Familial clusters of HBV infection with unfavorable prognoses refers to HBV-infected patients from two consecutive generations of blood relatives, with at least one family member diagnosed with hepatitis B-related cirrhosis or hepatocellular carcinoma (HCC). Previous family investigations have shown that the risk and harm of HBV-related cirrhosis and hepatocellular carcinoma are significantly higher in families with familial clusters of HBV infection with unfavorable prognoses than in the general population. Currently, antiviral drugs used for CHB mainly include nucleoside analogues (NAs) and interferon-alpha (mainly pegylated interferon-alpha, Peg IFN). NAs mainly inhibits viral replication by blocking the reverse transcription process, but it cannot effectively inhibit the expression of viral proteins such as HBsAg, and rarely achieves clinical cure. Multiple clinical studies have shown that the use of NAs reduces the incidence of cirrhosis decompensation, HCC, and death in patients with CHB compared to untreated or placebo-treated patients. Despite long-term treatment with first-line NAs drugs, CHB patients continue to be at risk of developing hepatocellular carcinoma. Peg IFN…
This description comes directly from the study's public registry record.
Yingren Zhao, Professor · 0086-029-85323437 · zhaoyingren@mail.xjtu.edu.cn
Ze Zhang · zz082089@126.com
Always discuss trial participation with your own doctor first.
| First Affiliated Hospital of Xian Jiaotong University | Xi'an, Shaanxi, China | Not Yet Recruiting |
| First Affiliated Hospital of Xian Jiaotong University | Xi'an, Shaanxi, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07079150