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Study identifier: NCT07076485 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

Condition: Breast Cancer  ·  Sponsor: M.D. Anderson Cancer Center

PhasePhase 2
Planned participants768
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning.

This description comes directly from the study's public registry record.

Talk to the study team

Benjamin Smith, MD  ·  (713) 563-2380  ·  bsmith3@mdanderson.org

Always discuss trial participation with your own doctor first.

Locations (4)

Banner MD Anderson Northern ColoradoLoveland, Colorado, United StatesRecruiting
Cooper Hospital University Medical CenterVoorhees Township, New Jersey, United StatesRecruiting
The University of Texas M. D. Anderson Cancer CenterHouston, Texas, United StatesRecruiting
University of Texas Health Science Center at San AntonioSan Antonio, Texas, United StatesRecruiting

Follow this study

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Source record: clinicaltrials.gov/study/NCT07076485