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Study identifier: NCT07074665 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Dose Finding Trial of R21/Matrix-M in School Children

Condition: Malaria (Plasmodium Falciparum)  ·  Sponsor: University of Oxford

PhasePhase 2
Planned participants40
Who can joinAll sexes, 6 Years to 8 Years
Healthy volunteersYes

About this study

This trial is a double-blind, randomised, trial recruiting participants from the R21 phase IIb trial (VAC 076) which took place between May 2019 and July 2023 in Nanoro, Burkina Faso. Participants (n=30-40) who have previously received four doses of the 5µg R21/50µg Matrix-M malaria vaccine in VAC 076 will be randomised to receive either 5µg R21/50µg Matrix-M or 10µg R21/50µg Matrix-M. Safety and immunogenicity of a booster at school age at these two different doses will be assessed. Participants will be followed up for one year after the booster.

This description comes directly from the study's public registry record.

Talk to the study team

Mehreen Datoo  ·  +44 7859035715  ·  mehreen.datoo@ndm.ox.ac.uk

Always discuss trial participation with your own doctor first.

Locations (1)

Unité de Recherche Clinique de Nanoro (URCN)Nanoro, Burkina FasoRecruiting

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Source record: clinicaltrials.gov/study/NCT07074665