Condition: Morbid Obesity Requiring Bariatric Surgery · Postoperative Pain · Postoperative Pain Management · Sponsor: Instituto Mexicano del Seguro Social
The goal of this randomized clinical trial is to find out whether giving an intravenous lidocaine + dexmedetomidine combination (LIDEX) during laparoscopic bariatric surgery can lower post-operative pain, inflammation, and oxidative stress in adults with obesity. The main questions it aims to answer are: * Pain control: Does LIDEX reduce pain 24 hours after surgery, as measured with the International Pain Outcomes Questionnaire (IPOQ)? * Biomarkers: Does LIDEX lower blood levels of key inflammatory cytokines-interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-10 (IL-10)-and oxidative-stress markers-malondialdehyde (MDA), the reduced/oxidized glutathione ratio (GSH/GSSG), superoxide dismutase (SOD), and catalase-compared with the individual drugs or saline placebo? Researchers will compare four groups: lidocaine alone, dexmedetomidine alone, LIDEX, and placebo (saline solution, a look-alike substance that contains no drug) to learn which approach works best. Participants will: * Receive an intravenous infusion of their assigned study drug(s) during surgery. * Provide three small blood samples (before surgery, immediately after, and three hours after). * Complete a short pain questionnaire (IPOQ) 24 hours after surgery.
This description comes directly from the study's public registry record.
Dulce M Rascón Martínez, Prof MD, MSc · + 52 55 5627 6900 · dradulcerascon@gmail.com
Arnulfo Calixto Flores, Prof MD, PhD · + 52 55 5627 6900 · drrufo@hotmail.com
Always discuss trial participation with your own doctor first.
| Hospital de Especialidades Centro Medico Nacional Siglo XXI | Mexico City, Mexico City, Mexico | Recruiting |
| Unidad Médica de Alta Especialidad Hospital de Especialidades del Centro Médico Nacional Siglo XXI | Mexico City, Mexico City, Mexico | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07073846