Condition: Intracranial Stenosis · Intracranial Atherosclerotic Disease · Sponsor: Insel Gruppe AG, University Hospital Bern
Background: Chronic intracranial large vessel occlusion (LVO), resulting from progressive atherosclerosis or thrombosis, contributes significantly to ischemic strokes, 8-10% in North America and up to 50% in the Chinese population. This condition leads to cerebral hypoperfusion, brain ischemia, and potentially cognitive impairment. While extra-to-intracranial bypass surgery has shown limited benefit, recent advances in endovascular treatment (EVT) for acute ischemic stroke show promise. Preliminary reports suggest EVT may be feasible for chronic intracranial artery occlusions. Still, outcomes vary and perioperative risks remain high, particularly for intradural occlusions, which are technically more challenging and less studied. Objectives: This study aims to evaluate the feasibility, safety, and clinical outcomes of EVT for symptomatic chronic intradural large vessel occlusions. Primary endpoints include technical success, complication rates, and functional outcomes, as measured by the modified Rankin Scale (mRS) at 3 months and the last follow-up. Safety endpoints include mortality, ischemic stroke, and periprocedural complications. Design: A multicenter, retrospective and prospective observational study involving 10-20 experienced centers worldwide. Data from approximately 40-80 patients treated between January 2020 and December 2024 will be collected by local neuroradiologists, neurologists, or neurosurgeons. Clinical data (demographics, comorbidities, symptoms, outcome…
This description comes directly from the study's public registry record.
Petra Cimflova, MD, PhD · +41316640831 · petra.cimflova@insel.ch
Jan Gralla, Prof. Dr. med. · +41316322654 · jan.gralla@insel.ch
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| Alfried Krupp Krankenhaus | Essen, Germany | Recruiting |
| Inselspital Bern, University Hospital Bern | Bern, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07072026