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Study identifier: NCT07071623 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)

Condition: Human Immunodeficiency Virus (HIV) · HIV Pre-Exposure Prophylaxis  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants4580
Who can joinFemale, 16 Years to 30 Years
Healthy volunteersYes

About this study

Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: * If taking MK-8527 once a month works to prevent HIV-1 infection better than a standard (usual) pre-exposure prophylaxis (PrEP) taken once a day * About the safety of MK-8527 and if people tolerate it

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (30)

UW - KNH; Rachuonyo County Hospital ( Site 0006)Homabay County, Homa Bay County, KenyaRecruiting
Partners in Health and Research Development (PHRD) ( Site 0002)Thika, Kiambu County, KenyaRecruiting
KEMRI-CMR-RCTP ( Site 0003)Nairobi, Kisumu County, KenyaRecruiting
Kargeno Research & Policy Hub ( Site 0007)Kisumu, KenyaRecruiting
Synergy Biomed Research Institute ( Site 0040)East London, Eastern Cape, South AfricaRecruiting
Foundation For Professional Development ( Site 0031)Ndevana, Eastern Cape, South AfricaRecruiting
Josha Research ( Site 0045)Bloemfontein, Free State, South AfricaRecruiting
Wits RHI Ward 21 Clinical Research site ( Site 0022)Johannesburg, Gauteng, South AfricaRecruiting
Helen Joseph Hospital-Clinical HIV Research Unit ( Site 0048)Johannesburg, Gauteng, South AfricaRecruiting
Perinatal HIV Research Unit (PHRU) ( Site 0033)Johnnesburg, Gauteng, South AfricaRecruiting
Setshaba Research Centre ( Site 0032)Pretoria, Gauteng, South AfricaRecruiting
SA Medical Research Council - Chatsworth Clinical Research Site ( Site 0026)Chatsworth, KwaZulu-Natal, South AfricaRecruiting

+ 18 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07071623