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Study identifier: NCT07070232 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

Condition: Advanced Solid Tumor  ·  Sponsor: BioNTech SE

PhasePhase 1/Phase 2
Planned participants1438
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will evaluate the safety, efficacy, optimal dose, and pharmacokinetics (PK) of BNT326 as monotherapy (Part 1) and as combination treatment with immunotherapeutic agents (Part 2) in participants with histologically or cytologically confirmed solid tumors that are advanced (i.e., either metastatic or recurrent tumors with no further definitive treatment possible) and/or have relapsed/progressed after prior therapy.

This description comes directly from the study's public registry record.

Talk to the study team

BioNTech clinical trials patient information  ·  +49 6131 9084  ·  patients@biontech.de

Always discuss trial participation with your own doctor first.

Locations (67)

Mayo Clinic ArizonaPhoenix, Arizona, United StatesNot Yet Recruiting
University of California San FranciscoSan Francisco, California, United StatesNot Yet Recruiting
Hartford HealthcareHartford, Connecticut, United StatesRecruiting
Yale UniversityNew Haven, Connecticut, United StatesRecruiting
Florida Cancer SpecialistsSarasota, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesNot Yet Recruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Brigitte Harris Cancer Pavilion BHCPDetroit, Michigan, United StatesRecruiting
START Midwest, LLCGrand Rapids, Michigan, United StatesRecruiting
Memorial Sloan Kettering HospitalNew York, New York, United StatesRecruiting
Duke Cancer InstituteDurham, North Carolina, United StatesNot Yet Recruiting

+ 55 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07070232