Condition: Multiple Sclerosis (MS) Primary Progressive · Sponsor: Zenas BioPharma (USA), LLC
Orelabrutinib is a CNS-penetrable BTK inhibitor. This is a phase 3, randomized, double-blind, parallel-group, multicenter study to evaluate the efficacy and safety of orelabrutinib compared with placebo in patients with PPMS. Patients will be treated for approximately 30 to 60 months, with a minimum treatment duration of 12 months. The study will enroll approximately 705 subjects in a 2:1 randomization (orelabrutinib: placebo), globally.
This description comes directly from the study's public registry record.
Patient and Medical Information · 833-269-4696 · clinicaltrialsinfo@zenasbio.com
Always discuss trial participation with your own doctor first.
| Arizona Neuroscience Research, LLC | Pheonix, Arizona, United States | Recruiting |
| Perseverance Research Center | Scottsdale, Arizona, United States | Recruiting |
| Regina Berkovich MD, PhD Inc. | West Hollywood, California, United States | Recruiting |
| Nova Clinical Research, LLC | Bradenton, Florida, United States | Recruiting |
| Neurology Associates, PA | Maitland, Florida, United States | Recruiting |
| KC Research Center, PA Neurology Research Department | Roeland Park, Kansas, United States | Recruiting |
| Washington University School of Medicine | St Louis, Missouri, United States | Recruiting |
| Cooperman Barnabas Medical Center | Livingston, New Jersey, United States | Recruiting |
| Velocity Clinical Research, Raleigh Neurology | Raleigh, North Carolina, United States | Recruiting |
| The Boster Center for Multiple Sclerosis | Columbus, Ohio, United States | Recruiting |
| Premier Neurology | Greenville, South Carolina, United States | Recruiting |
| Neurology Clinic, P.C. | Cordova, Tennessee, United States | Recruiting |
+ 28 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07067463