Condition: Endometrial Cancer · Obesity · Sponsor: UNC Lineberger Comprehensive Cancer Center
LCCC2415 examines the antiproliferative effect of tirzepatide on the endometrium of endometrial cancer (EC). This is a pre-operative window clinical study. Endometrial biopsy samples from patients before tirzepatide treatment will be compared to their post-intervention hysterectomy specimens. If archival tissue is unavailable, a fresh biopsy will be taken before tirzepatide treatment. Post-intervention tissue will be collected from the hysterectomy specimen. The hypothesis is that tirzepatide's anti-tumorigenic effects are due to both an improvement in the host's metabolic milieu (indirect effect) and a direct effect on the EC tumor microenvironment via the inter-related pathways of insulin, lipid, and mTOR signaling. Therefore, tirzepatide may be an innovative approach to effectively induce weight loss and inhibit tumor growth in EC, the most obesity-driven of all cancers.
This description comes directly from the study's public registry record.
Luz Cuaboy · +1 919-966-4432 · luz_cuaboy@med.unc.edu
Emmie Cole · +1 919-966-4432 · emmie_cole@med.unc.edu
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| Lineberger Comprehensive Cancer Center | Chapel Hill, North Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07065552