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Study identifier: NCT07064083 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

The Effect of Intra-Canal Ketorolac Application on Post-Endodontic Pain

Condition: To Evaluate the Effectiveness of Intra-canal Nano-ketrolac as a Medicament in Reducing Post-endodontic Pain in Patients Undergoing Root Canal Treatment  ·  Sponsor: Al-Azhar University

PhaseEARLY_Phase 1
Planned participants36
Who can joinAll sexes, 18 Years to 50 Years
Healthy volunteersYes

About this study

After obtaining informed consent, the procedure begins with the administration of local anesthesia to ensure patient comfort. A standard approach involves using 2% lidocaine with 1:100,000 epinephrine, delivered either via infiltration for maxillary teeth or mental nerve block for mandibular posterior teeth. Adequate anesthesia is confirmed using a cold test or gentle probing. Once profound anesthesia is achieved, rubber dam isolation is placed to maintain an aseptic field and prevent contamination. The operative field is then disinfected with 5% sodium hypochlorite before proceeding to the access cavity preparation. The access cavity is prepared using a high-speed diamond bur under continuous water coolant. The shape of the access cavity is determined by the tooth's anatomy, ensuring straight-line access to the canal system. Once the pulp chamber is opened, the roof is carefully removed using a round bur or ultrasonic tips, exposing the canal orifices. The chamber is then thoroughly irrigated with 2.5% sodium hypochlorite to remove any residual pulp tissue and debris. A DG16 endodontic explorer is used to locate the canal orifices, after which initial canal exploration is performed using a #10 or #15 K-file to check for patency. Working length determination follows, utilizing an electronic apex locator (EAL) to establish the length of the canal. A confirmation periapical radiograph is taken to verify the readings. To maintain apical patience, a #10 K-file is used in a gent…

This description comes directly from the study's public registry record.

Talk to the study team

Sabah Sobhy, PHD  ·  01096529143  ·  sabamorad@yahoo.com

Sabah M. Sobhy, PH  ·  01096529143  ·  sabamorad@yahoo.com

Always discuss trial participation with your own doctor first.

Locations (1)

Collage of Oral and Dental Surgery, Misr University for Science and TechnologyGiza, EgyptRecruiting

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Source record: clinicaltrials.gov/study/NCT07064083