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Study identifier: NCT07063745 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

Condition: Metastatic Non-small Cell Lung Cancer With MTAP Deletion  ·  Sponsor: Bristol-Myers Squibb

PhasePhase 2/Phase 3
Planned participants590
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to compare the clinical benefit of the combination of Navlimetostat (BMS-986504) (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion

This description comes directly from the study's public registry record.

Talk to the study team

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com  ·  855-907-3286  ·  Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

Always discuss trial participation with your own doctor first.

Locations (318)

Alaska Oncology and HematologyAnchorage, Alaska, United StatesRecruiting
Mayo Clinic in Arizona - PhoenixPhoenix, Arizona, United StatesRecruiting
University of Arizona Cancer CenterTucson, Arizona, United StatesRecruiting
Highlands Oncology GroupSpringdale, Arkansas, United StatesRecruiting
Local Institution - 0497Los Alamitos, California, United StatesNot Yet Recruiting
USC/Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
Local Institution - 0444Los Angeles, California, United StatesWithdrawn
Local Institution - 0606Newark, Delaware, United StatesWithdrawn
Helios Clinical Research - Fort LauderdaleFort Lauderdale, Florida, United StatesRecruiting
Mayo Clinic in FloridaJacksonville, Florida, United StatesRecruiting
Local Institution - 0430St. Petersburg, Florida, United StatesWithdrawn
Local Institution - 0523Tampa, Florida, United StatesNot Yet Recruiting

+ 306 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07063745