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Study identifier: NCT07058077 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)

Condition: Heterozygous Familial Hypercholesterolemia (HeFH)  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2/Phase 3
Planned participants153
Who can joinAll sexes, 6 Years to 17 Years
Healthy volunteersNo

About this study

This study is designed to learn if enlicitide decanoate is safe and effective to treat children and adolescents with heterozygous familial hypercholesterolemia (HeFH) and high amounts of low-density lipoprotein cholesterol (LDL-C) in the blood. The goals of this study are to learn about the safety of enlicitide and if children tolerate it, what happens to enlicitide in a child's body over time, and if enlicitide works to lower cholesterol levels in children more than a placebo.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (36)

Nemours/Alfred I. duPont Hospital for Children ( Site 0001)Wilmington, Delaware, United StatesRecruiting
Children's National Medical Center ( Site 0015)Washington D.C., District of Columbia, United StatesRecruiting
Excel Medical Clinical Trials ( Site 0008)Boca Raton, Florida, United StatesRecruiting
Children's Healthcare of Atlanta Cardiology ( Site 0026)Atlanta, Georgia, United StatesRecruiting
Boston Children's Hospital ( Site 0018)Boston, Massachusetts, United StatesRecruiting
Cincinnati Children's Hospital Medical Center ( Site 0016)Cincinnati, Ohio, United StatesRecruiting
West Virginia University ( Site 0013)Morgantown, West Virginia, United StatesRecruiting
Monash Children s Hospital ( Site 1603)Clayton, Victoria, AustraliaRecruiting
UZ Antwerpen ( Site 0601)Edegem, Antwerpen, BelgiumRecruiting
Universidade Federal Do Ceara ( Site 0201)Fortaleza, Ceará, BrazilRecruiting
Instituto Dante Pazzanese de Cardiology ( Site 0206)São Paulo, BrazilRecruiting
Incor - Instituto do Coracao ( Site 0200)São Paulo, BrazilRecruiting

+ 24 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07058077