Condition: Type1diabetes · Sponsor: The University of Texas Health Science Center at San Antonio
Participants are being asked to be in a research study. Scientists do research to answer important questions which might help change or improve treatment of participants disease in the future. In patients with Type 1 Diabetes (T1D), dapagliflozin a Selective Glucose Transporter 2 Inhibitor (SGLT2i) is known to increase production of glucose in the liver, increase breakdown of fats (lipolysis), and increase production of ketones (ketogenesis). Ketones are chemicals produced by the liver when the body breaks down fat for energy instead of glucose. When the level of ketones in the body becomes too high, a condition called ketoacidosis develops. In this study, the study team will investigate whether adding pioglitazone (a medication commonly used to treat type 2 diabetes), can reduce the dapagliflozin - induced liver glucose production, fat break down (lipolysis) and ketone body production (ketogenesis) in patients with T1D.
This description comes directly from the study's public registry record.
Ralph DeFronzo, MD · 210 567 6691 · defronzo@uthscsa.edu
Aurora Merovci, MD, MPH · 210 358 7409 · merovci@uthscsa.edu
Always discuss trial participation with your own doctor first.
| Texas Diabetes Institute | San Antonio, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07056699