Condition: Liver Diseases · Liver Cancer · Liver Cirrhosis · Sponsor: AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC
This early-phase clinical trial will assess the use of ex vivo CRISPR-Cas9 genome editing on donor liver grafts to reduce immunogenicity before transplantation. Donor livers will have HLA-A and HLA-B genes knocked out, and HLA class II expression disabled (by targeting the CIITA transactivator gene), aiming to create a "hypoimmunogenic" organ less prone to rejection. The edited liver is then transplanted into patients with end-stage liver disease. The primary focus is on safety and feasibility - determining whether a CRISPR-edited liver can be transplanted successfully and function normally - as well as evaluating reductions in immune response (acute rejection, anti-donor T cell activation) and graft function over time.
This description comes directly from the study's public registry record.
Andrew R Linehan · +1 (302) 615-8388 · clinical-trials@aotcri.org
Always discuss trial participation with your own doctor first.
| Peking University Health Science Center (PKUHSC) | Beijing, Changping, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07053488