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Study identifier: NCT07053423 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

Condition: Chronic Obstructive Pulmonary Disease  ·  Sponsor: Sanofi

PhasePhase 4
Planned participants218
Who can joinAll sexes, 40 Years to 85 Years
Healthy volunteersNo

About this study

LPS18583 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 4 study with 2 treatment groups. The purpose of this study is to assess the effect of dupilumab compared with placebo on airway inflammation, resistance, and remodeling including mucus plugging and its association with improvement on lung function, exacerbations, and quality of life improvement in participants aged 40 years of age up to 85 years of age (inclusive). Study details include: The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The number of visits will be 9.

This description comes directly from the study's public registry record.

Talk to the study team

Trial Transparency email recommended (Toll free for US & Canada)  ·  800-633-1610  ·  contact-us@sanofi.com

Always discuss trial participation with your own doctor first.

Locations (68)

University of Alabama at Birmingham - School of Medicine- Site Number : 8400003Birmingham, Alabama, United StatesRecruiting
Finlay Medical Research- Site Number : 8400010Miami, Florida, United StatesRecruiting
Private Practice - Dr. David Kavtaradze- Site Number : 8400017Cordele, Georgia, United StatesRecruiting
University of Kansas Medical Center- Site Number : 8400005Kansas City, Kansas, United StatesRecruiting
Johns Hopkins Bayview Medical Center- Site Number : 8400009Baltimore, Maryland, United StatesRecruiting
Brigham & Women's Hospital- Site Number : 8400014Boston, Massachusetts, United StatesRecruiting
American Health Research - Charlotte- Site Number : 8400013Charlotte, North Carolina, United StatesRecruiting
Atrium Health Wake Forest Baptist Pulmonary, Sleep And Allergy- Site Number : 8400004Winston-Salem, North Carolina, United StatesRecruiting
Clinical Research Associates of Central Pennsylvania- Site Number : 8400002DuBois, Pennsylvania, United StatesRecruiting
REX Clinical Trials - Beaumont- Site Number : 8400011Beaumont, Texas, United StatesRecruiting
Investigational Site Number : 0320001San Miguel de Tucumán, Tucumán Province, ArgentinaRecruiting
Investigational Site Number : 0320002Buenos Aires, ArgentinaRecruiting

+ 56 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07053423