Condition: Type 2 Diabetes · Sponsor: The University of Texas Health Science Center at San Antonio
In this study, PI will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) that the increases in ketone production and lipolysis can be prevented by concomitant administration of the thiazolidinedione pioglitazone. Principal Investigator (PI) will conduct five distinct experiments to test this hypothesis in patients with T2D. To examine the role of the SNS on the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D by comparing the effect of empagliflozin versus empagliflozin plus propranolol.
This description comes directly from the study's public registry record.
Ralph DeFronzo, MD · 210-567-6691 · defronzo@uthscsa.edu
Aurora Merovci, MD · 210-567-6691 · merovci@uthscsa.edu
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| Texas Diabetes Institute/UH | San Antonio, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07053293