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Study identifier: NCT07052370 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies

Condition: Hematologic Malignancy  ·  Sponsor: St. Jude Children's Research Hospital

PhasePhase 1
Planned participants30
Who can joinAll sexes, N/A to 21 Years
Healthy volunteersYes

About this study

This is a phase I, prospective clinical trial studying the safety and feasibility of providing early memory T-cell DLI. The primary objective is: \- To assess the safety and feasibility of early CD45RA-depleted DLI administration. The secondary objectives are * To assess the safety and feasibility of the addition of blinatumomab in the early post-transplant period in patients with CD19+ malignancy. * To measure and describe the pharmacokinetics of rabbit ATG in HCT recipients on this study.

This description comes directly from the study's public registry record.

Talk to the study team

Brandon Triplett, MD  ·  8662785833  ·  referralinfo@stjude.org

Always discuss trial participation with your own doctor first.

Locations (1)

St. Jude Children's Research HospitalMemphis, Tennessee, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07052370