Condition: Arteriovenous Malformation of Central Nervous System · Aneurysm, Ruptured · Aneurysmatic Subarachnoid Haemorrhage · Sponsor: The First Affiliated Hospital with Nanjing Medical University
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.
This description comes directly from the study's public registry record.
Yifei Wang · +86-13852665323 · wangyifei5323@163.com
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| Jiangsu Province Hospital | Nanjing, Jiangsu, China | Active Not Recruiting |
| the First Affiliated Hospital of Nanjing Medical University | Nanjing, Jiangsu, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07050381