Condition: Renal Cell Carcinoma · Sponsor: Merck Sharp & Dohme LLC
Substudy 03C is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy 03C is to evaluate the safety and efficacy of experimental combinations of investigational agents in participants with clear cell renal cell carcinoma (ccRCC) who have recurrent disease during or after anti-programmed cell death 1/programmed cell death ligand 1 (PD-\[L\]1) adjuvant therapy. This substudy will have two phases: a safety lead-in phase and an efficacy phase. The safety lead-in phase will be used to demonstrate a tolerable safety profile for the combination of investigational agents. There will be no hypothesis testing in this study
This description comes directly from the study's public registry record.
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| UCSF Medical Center at Mission Bay ( Site 5008) | San Francisco, California, United States | Recruiting |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 5026) | Mineola, New York, United States | Recruiting |
| Laura and Isaac Perlmutter Cancer Center ( Site 5016) | New York, New York, United States | Recruiting |
| Memorial Sloan Kettering Cancer Center ( Site 5002) | New York, New York, United States | Recruiting |
| Duke Cancer Institute ( Site 5015) | Durham, North Carolina, United States | Recruiting |
| UPMC Cancer Center/Hillman Cancer Center ( Site 5017) | Pittsburgh, Pennsylvania, United States | Recruiting |
| Vanderbilt University Medical Center ( Site 5004) | Nashville, Tennessee, United States | Recruiting |
| Centro de Estudios Clínicos SAGA ( Site 6110) | Santiago, Region M. de Santiago, Chile | Recruiting |
| Bradfordhill ( Site 6101) | Santiago, Region M. de Santiago, Chile | Recruiting |
| C.H.U. de Strasbourg Hopital de Hautepierre ( Site 5203) | Strasbourg, Bas-Rhin, France | Recruiting |
| Institut Claudius Regaud ( Site 5200) | Toulouse, Haute-Garonne, France | Recruiting |
| Centre Eugene Marquis ( Site 5205) | Rennes, Ille-et-Vilaine, France | Recruiting |
+ 18 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07049926