Condition: Shigella · Sponsor: Eveliqure Biotechnologies GmbH
The purpose of this study is to evaluate the efficacy of the oral, live, attenuated ShigETEC vaccine against challenge with S. flexneri 2457T. In Stage 1 of this study, ShigETEC vaccine or placebo will be administered orally to healthy participants at a dose of 5x10\^10 CFU. This dose was tested in a Phase 1 trial and found to be safe when given 4 times with an interval of 3 days between each dose. The efficacy of ShigETEC vaccination will be evaluated in Stage 2 of this study, when participants will be challenged with S. flexneri 2457T. The study population will be healthy adult participants in the age of 18-50 years (inclusive), which are clearly defined in the study protocol.
This description comes directly from the study's public registry record.
Kawsar Talaat, MD · +1 410-955-7283 · ktalaat@jhu.edu
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| Center for Immunization Research | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07049159