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Study identifier: NCT07044297 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

Condition: Human Immunodeficiency Virus (HIV) · HIV Pre-Exposure Prophylaxis  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants4390
Who can joinAll sexes, 16 Years to no upper limit
Healthy volunteersYes

About this study

Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: * If taking MK-8527 once a month works to prevent HIV-1 infection as well as or better than a standard (usual) pre-exposure prophylaxis (PrEP) taken once a day * About the safety of MK-8527 and if people tolerate it

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (81)

University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 0006)Birmingham, Alabama, United StatesRecruiting
USA Health University Hospitals ( Site 0020)Mobile, Alabama, United StatesRecruiting
UCLA Center for Clinical AIDS Research and Education ( Site 0004)Los Angeles, California, United StatesRecruiting
Bridge HIV - San Francisco Department of Public Health ( Site 0001)San Francisco, California, United StatesRecruiting
Whitman-Walker Institute ( Site 0016)Washington D.C., District of Columbia, United StatesRecruiting
University of Miami RAPID Research ( Site 0003)Miami, Florida, United StatesRecruiting
Orlando Immunology Center ( Site 0021)Orlando, Florida, United StatesRecruiting
Hope Clinic of the Emory Vaccine Center ( Site 0009)Decatur, Georgia, United StatesRecruiting
University of Illinois Chicago ( Site 0027)Chicago, Illinois, United StatesRecruiting
University Medical Center New Orleans ( Site 0024)New Orleans, Louisiana, United StatesRecruiting
Open Arms Healthcare Center ( Site 0025)Jackson, Mississippi, United StatesRecruiting
Rutgers New Jersey Medical School ( Site 0010)Newark, New Jersey, United StatesRecruiting

+ 69 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07044297