Condition: Localized Prostate Adenocarcinoma · Sponsor: University of Zurich
Hip replacements and prostate cancer are independently and both together increasing prevalent in the aging population. In the United States, the prevalence of hip prostheses among men was 1.1 million in 20101, with approximately 500,000 hip prostheses performed annually. Bilateral total hip replacement is recommended for patients with osteoarthritis affecting both hip joints. Approximately 10-25% of total hip replacement patients undergo bilateral procedures. Stereotactic body radiotherapy (SBRT) has been widely adopted as an effective treatment for localized prostate cancer, offering high precision and reduced treatment time due to conventionally fractionated radiotherapy without increasing toxicity or comprising oncological outcomes. Therefore, the use of SBRT for treatment of localized prostate cancer has significantly increased. A cohort study using data from 302 035 patients in the National Cancer Database showed that use of SBRT for prostate cancer increased from 0.2% in 2004 to 12.4% in 2020 in the United States. However, both CT and MR-guided SBRT present unique challenges for patients with prostate cancer and bilateral hip prostheses. Metallic implants, such as hip prostheses, produce artifacts and magnetic susceptibility issues that can obscure MR imaging near the prosthetic sites, potentially complicating target contouring and planning. Given the close proximity of the prostate gland to the pelvis, which houses the hip joints, patients with bilateral hip prosthese…
This description comes directly from the study's public registry record.
Matthias Guckenberger, Prof. Dr. med. · +41442553566 · Matthias.Guckenberger@usz.ch
Tiuri E. Kroese, Dr. med. · +41442553566 · tiuri.kroese@usz.ch
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| University Hospital Zurich, Department of Radio-Oncology | Zurich, Canton of Zurich, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07042256