Condition: Acute Lymphobkastic Leukemia · Acute Lymphoblastic Leukaemia Recurrent · Philadelphia Chromosome Negative ALL · Sponsor: Hospital Universitario Dr. Jose E. Gonzalez
Relapsed/refractory acute lymphoblastic leukemia remains a challenge in the context of limited access to immunotherapy in developing countries. With such poor 5-year overall survival rates of 10%, the investigators need strategies that surpass the complete response rate achieved in this setting, which does not exceed 60% effectiveness with different regimens, and to eventually transfer patients to hematopoietic stem cell transplantation. In this context, the investigators are studyng if the use of venetoclax, a BCL2 inhibitor, with the use of a cytochrome p450 inhibitor such as itraconazole, alongside the TACL chemotherapy regimen, which is based on the combination of asparaginase, dexamethasone, bortezomib, vincristine, and mitoxantrone.
This description comes directly from the study's public registry record.
Andres Gomez-De Leon, Professor of Hematology · +528116089404 · drgomezdeleon@gmail.com
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| Hospital Universitario Dr. Jose E. Gonzalez | Monterrey, Nuevo León, Mexico | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07039877