● Recruiting

A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

Condition: Homozygous Familial Hypercholesterolemia · Sponsor: Arrowhead Pharmaceuticals

PhasePhase 3

Planned participants60

Who can joinAll sexes, 12 Years to no upper limit

Healthy volunteersNo

About this study

This multicenter, randomized, placebo-controlled study will evaluate the efficacy and safety of zodasiran subcutaneous (SC) injection in subjects 12 years of age and older with genetically or clinically diagnosed Homozygous familial hypercholesterolemia (HoFH). After completion of the double blind (DB) treatment period subjects will be eligible to continue in the optional open-label extension (OLE) period of the study. All placebo subjects who opt to continue will transition to active drug during the OLE Period.

This description comes directly from the study's public registry record.

Talk to the study team

Medical Monitor · 626-304-3400 · YOSEMITE@arrowheadpharma.com

Always discuss trial participation with your own doctor first.

Locations (43)

Research Site 7	Park Ridge, Illinois, United States	Recruiting
Research Site 2	New York, New York, United States	Recruiting
Research Site 1	Cincinnati, Ohio, United States	Recruiting
Research Site 14	Pittsburgh, Pennsylvania, United States	Recruiting
Research Site 13	Camperdown, New South Wales, Australia	Recruiting
Research Site 9	Saint Leonards, New South Wales, Australia	Recruiting
Research Site 21	Heidelberg, Victoria, Australia	Recruiting
Research Site 3	Nedlands, Western Australia, Australia	Recruiting
Research Site 40	Innsbruck, Austria	Recruiting
Research Site 39	Linz, Austria	Recruiting
Research Site 42	Vienna, Austria	Recruiting
Research Site 37	Vienna, Austria	Recruiting

+ 31 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07037771