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Study identifier: NCT07036146 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Single-center Transversal Observational Study on the Evaluation of S100B Changes in Subjects Attending the Emergency Department With Head Trauma

Condition: Head Trauma  ·  Sponsor: IRCCS San Raffaele

PhaseN/A
Planned participants1000
Who can joinAll sexes, N/A to 100 Years
Healthy volunteersNo

About this study

The aim of the study is to evaluate blood levels of the calcium-binding protein S100B as a diagnostic biomarker for the management of patients with suspected traumatic brain injury. With a sensitivity of 97% and a negative predictive value greater than 99%, S100B measurement can predict the absence of brain injury, supporting risk stratification and the safe discharge of low-risk patients. This, in turn, may reduce the need for imaging studies and shorten emergency department stays. The management of patients enrolled in the study will be identical to that of non-enrolled patients. The only difference is that patients in the study will undergo a blood draw, whereas in routine practice blood tests are not mandatory (although they are often performed).

This description comes directly from the study's public registry record.

Talk to the study team

Eleonora Sabetta, Doctor  ·  +39 0226435288  ·  sabetta.eleonora@hsr.it

Always discuss trial participation with your own doctor first.

Locations (1)

IRCCS Ospedale San RaffaeleMilan, Milano, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07036146