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Study identifier: NCT07036133 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

Condition: Advanced Solid Tumors · Hematologic Malignancies  ·  Sponsor: Acrotech Biopharma Inc.

PhasePhase 1
Planned participants24
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This purpose of this study is to help to evaluate the pharmacokinetic (PK) profile of pralatrexate when administered to patients with various degrees of hepatic impairment and to evaluate the safety and establish the dosing recommendations for pralatrexate administered once weekly for 6 weeks of every 7-week treatment cycle in patients with hepatic impairment. Pharmacokinetics (or PK) is the study of how your body absorbs, breaks down, and removes a study drug.

This description comes directly from the study's public registry record.

Talk to the study team

Uma Srinivas Atmuri  ·  732-917-2420  ·  uatmuri@acrotechbiopharma.com

Motun Clinical Trial Manager  ·  617-694-4296  ·  msolomon@acrotechbiopharma.com

Always discuss trial participation with your own doctor first.

Locations (4)

TOI Clinical ResearchCerritos, California, United StatesWithdrawn
Northwestern University - Feinberg School of MedicineChicago, Illinois, United StatesRecruiting
Karmanos Cancer InstituteDetroit, Michigan, United StatesRecruiting
Gabrail Cancer CenterCanton, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07036133