Condition: Common Bile Duct Stone · Sponsor: Mahidol University
Common bile duct (CBD) stones are a frequent condition that can lead to severe complications if not treated. The standard approach involves endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy and stone extraction using balloons or baskets. However, approximately 10-15% of cases involve "difficult CBD stones" that cannot be removed using conventional methods. According to the European Society of Gastrointestinal Endoscopy (ESGE), difficult CBD stones are characterized by large size (≥15 mm), impaction, multiple stones, difficult locations (e.g., intrahepatic or cystic ducts), or altered anatomy due to previous surgeries. These cases require advanced techniques such as single-operator cholangioscopy (SOC) using the SpyGlass DS system, which allows direct stone visualization and lithotripsy-assisted fragmentation. Two primary lithotripsy methods are available: Electrohydraulic Lithotripsy (EHL): Uses shock waves from electrical energy to break stones. Laser Lithotripsy (LL): Uses laser energy to fragment stones through a water-mediated medium. While both techniques are effective, studies suggest LL has a higher first-attempt stone clearance rate (82-100%) compared to EHL (70.9-75%). However, EHL is more cost-effective and widely available, whereas LL offers greater precision but at a higher cost. Currently, no randomized controlled trial (RCT) directly compares their efficacy, procedural time, complication rates, or operator satisfaction. This study a…
This description comes directly from the study's public registry record.
Ronnakorn Kongsakon, MD · +66655979522 · ronnagorn@gmail.com
Chutikarn Wittayalikit, MD · +66986899088 · Chutikarn_witt@hotmail.com
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| Faculty of Medicine Siriraj Hospital, Mahidol University | Bangkok, Bangkok, Thailand | Recruiting |
| Faculty of Medicine Siriraj Hospital, Mahidol University | Bangkok, Bangkok, Thailand | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07030829