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Study identifier: NCT07029828 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata.

Condition: Severe Alopecia Areata  ·  Sponsor: Pfizer

PhasePhase 3
Planned participants140
Who can joinAll sexes, 6 Years to 14 Years
Healthy volunteersNo

About this study

The purpose of this clinical trial is to learn about long-term safety and long-term effects of the study medicine (called ritlecitinib) for the potential treatment of severe alopecia areata, a condition that causes hair loss. This study is seeking participants who have: * previously completed one of Pfizer's pediatric studies for Alopecia Areata (B7981027 or B7981031). * at least 50% scalp hair loss due to alopecia areata (for participants enrolling from the study B7981031). * received varicella vaccination (2 doses) or have been infected by varicella zoster virus before based on blood test reports. All participants in this study will receive the study medicine (ritlecitinib). Participants who received ritlecitinib higher or lower doses in the parent Study B7981027 will continue receiving the same ritlecitinib dose in this trial. Participants who received placebo in the parent Study B7981027 and all participants from parent Study B7981031 will receive either higher or lower dose of ritlecitinib in this trial. The study medicine is a capsule that is taken by mouth. It is taken 1 time each day at home. The study will help see if ritlecitinib is safe and effective. Participants will take part in this study for a duration of up to 3 years (36 months). During this time, they will have 17 study visits at the study clinic. The study team will also call participants once a month over the phone.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (41)

California Dermatology & Clinical Research InstituteEncinitas, California, United StatesRecruiting
Pediatric Skin ResearchMiami, Florida, United StatesRecruiting
D&H Tamarac Research CenterTamarac, Florida, United StatesNot Yet Recruiting
Dawes Fretzin Clinical Research Group, LLCIndianapolis, Indiana, United StatesRecruiting
Kindred Hair and Skin CenterMarriottsville, Maryland, United StatesNot Yet Recruiting
Michigan Dermatology InstituteWaterford, Michigan, United StatesNot Yet Recruiting
Ear, Nose & Throat Consultants, LLCOmaha, Nebraska, United StatesRecruiting
Skin Specialists, PC dba Schlessinger MDOmaha, Nebraska, United StatesRecruiting
Complete Behavior Health (Dr. Brittany Marshall, Licensed Psychologist)Papillion, Nebraska, United StatesRecruiting
University of New Mexico Health Sciences CenterAlbuquerque, New Mexico, United StatesRecruiting
University of New Mexico-IDS PharmacyAlbuquerque, New Mexico, United StatesRecruiting
Regents of the University of New MexicoAlbuquerque, New Mexico, United StatesRecruiting

+ 29 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07029828