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Study identifier: NCT07028853 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Condition: Metastatic Castration Sensitive Prostate Cancer (mCSPC) · Hormone Sensitive Prostate Cancer · Prostate Cancer  ·  Sponsor: Pfizer

PhasePhase 3
Planned participants1000
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will explore whether a combination of the investigational drug mevrometostat (PF-06821497) and enzalutamide will work better than taking enzalutamide alone in participants with mCSPC who are ARPI naïve and have not yet received chemotherapy in the mCSPC setting.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (341)

Clearview Cancer Institute (Crestwood)Huntsville, Alabama, United StatesRecruiting
Clearview Cancer InstituteHuntsville, Alabama, United StatesRecruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research CentersChandler, Arizona, United StatesRecruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research CentersGilbert, Arizona, United StatesRecruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research CentersGlendale, Arizona, United StatesRecruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research CentersGoodyear, Arizona, United StatesRecruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research CentersMesa, Arizona, United StatesRecruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research CentersMesa, Arizona, United StatesRecruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research CentersPhoenix, Arizona, United StatesRecruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research CentersScottsdale, Arizona, United StatesRecruiting
Highlands Oncology Group, PAFayetteville, Arkansas, United StatesRecruiting
Highlands Oncology Group, PARogers, Arkansas, United StatesRecruiting

+ 329 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07028853