Condition: Cardiac Arrest (CA) · Resuscitated Sudden Cardiac Death · Post Cardiac Arrest Patient Who Was Treated by Hypothermia Protocol · Sponsor: Assistance Publique - Hôpitaux de Paris
Less than 10% of patients eliciting out-of-hospital cardiac arrest (OHCA) survive, although 30% can be resuscitated by Emergency services before admission in Intensive Care Units (ICU). The majority succumb to Post-Cardiac Arrest Syndrome (PCAS). PCAS is associated with high mortality (60-70%) and morbidity. One proposed method of preventing the neurological and cardiac consequences of PCAS is to lower the body temperature to 33°C as quickly as possible. This approach is known as therapeutic hypothermia or Targeted Temperature Management (TTM). The Vent2Cool system, developed by Orixha, is a novel approach that enables the rapid induction of therapeutic hypothermia by using hypothermic Total Liquid Ventilation (TLV) to reach a protective temperature of 33°C within minutes. The OverCool feasibility study, which started in April 2025, is designed to validate the clinical performance and safety of an ultra-rapid cooling approach combining ultra-rapid hypothermia induction using the Vent2Cool system, and maintenance and rewarming using the ArcticSun system. The AfterCool study aims to evaluate long-term outcomes during a five-year follow-up of cardiac arrest survivors who were treated with ultrarapid cooling in the OverCool study.
This description comes directly from the study's public registry record.
Alain CARIOU, MD PhD · +33 1 58 41 25 01 · alain.cariou@aphp.fr
Always discuss trial participation with your own doctor first.
| Angers University Hospital, Medical Intensive Care Unit, Vent'Lab | Angers, France | Not Yet Recruiting |
| AP-HP Centre, Cochin Hospital, Medical Intensive Care Unit | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07028372