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Study identifier: NCT07027748 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma

Condition: Neuroblastoma · Neuroblastoma Recurrent · Relapsed Neuroblastoma  ·  Sponsor: Steven DuBois, MD

PhasePhase 1
Planned participants18
Who can joinAll sexes, 1 Year to 30 Years
Healthy volunteersNo

About this study

This research is being done to investigate a treatment regimen of Irinotecan, Temozolomide, and Sargramostin, and an immunotherapy called Naxitamab and whether giving Naxitamab more slowly reduces the side effects for participants with relapsed or refractory neuroblastoma. The name of the study drugs involved in this study are: * Naxitamab (A type of monoclonal antibody) * Irinotecan (A standard of care chemotherapy) * Temozolomide (A standard of care chemotherapy) * Sargramostim (A standard of care, granulocyte-macrophage colony stimulating factor)

This description comes directly from the study's public registry record.

Talk to the study team

Steven DuBois, MD, MS  ·  617-632-5460  ·  Steven_Dubois@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07027748