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Study identifier: NCT07027488 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

AB821 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

Condition: Advanced Melanoma and Normal or Impaired · Advanced Melanoma  ·  Sponsor: Yale University

PhasePhase 1
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

This study is a first-in-human, open-label, nonrandomized, single center Phase 1 dose-escalation study to assess the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary antitumor activity of AB821 monotherapy given every 2 weeks (Q2W) or every 3 weeks (Q3W) in participants with recurrent locally advanced or metastatic melanoma and other immune-responsive solid tumors. Immune-responsive solid tumors are defined as those for which immune checkpoint inhibitors form part of the standard-of-care therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Stephanie Ladd  ·  203-785-5702  ·  stephanie.ladd@yale.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Yale UniversityNew Haven, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07027488