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Study identifier: NCT07027345 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase II, Placebo Controlled, Clinical Trial of Topical TolaSure Targeting Aggregated Mutant Keratin in Epidermolysis Bullosa Simplex

Condition: Epidermolysis Bullosa Simplex  ·  Sponsor: BioMendics, LLC

PhasePhase 2
Planned participants40
Who can joinAll sexes, 4 Years to no upper limit
Healthy volunteersNo

About this study

This Phase II clinical study will assess the efficacy, safety and tolerability of topical TolaSure Gel in adults and pediatric patients (4 years of age and older) diagnosed with generalized intermediate to severe epidermolysis bullosa simplex (EBS). Each patient (40 to complete) will be enrolled in the study and will be randomized to receive either TolaSure Gel or a topical Placebo for daily application for 2-months. After 2-months, all patients will receive TolaSure Gel to daily apply for an additional 2-months. A remote follow-up visit will occur 2-months after the end of study. Total time in the study is 6-months. Patients will be applying study medication to randomized treatment area(s) (a minimum of \~2-3% Body Surface Area (BSA)), with the option to treat their feet as well throughout the study.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (2)

Stanford University School of Medicine, Dermatology DepartmentPalo Alto, California, United StatesRecruiting
NU Dermatolgy CTUChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07027345