Condition: Spinal Stenosis of Lumbar Region · Spine Degeneration · Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Background Lumbar spinal stenosis (LSS) is a common condition characterized by spinal canal narrowing, often linked to ligamentum flavum hypertrophy (LFH) and degeneration. Fibrotic processes involving elastin and collagen alterations contribute to LF thickening and spinal instability. Despite progress, the molecular mechanisms underlying LFH remain unclear, necessitating targeted diagnostic and therapeutic strategies. Objective This study aims to analyze the proteomic and histological changes in LFH associated with LSS, correlating molecular signatures with imaging and surgical findings to identify potential therapeutic targets. Methods LF samples from LSS patients undergoing surgery will be analyzed using mass spectrometry-based proteomics and histology to identify biomarkers and molecular pathways. Correlations between imaging, intraoperative findings, and molecular profiles will be assessed. Expected Results The study aims to identify specific biomarkers and molecular pathways involved in LFH, linking them to clinical and imaging findings. Statistical analyses will evaluate associations between molecular alterations and surgical outcomes to define therapeutic targets. Significance By identifying molecular markers of LFH, this research aims to improve LSS diagnosis and treatment, potentially guiding targeted therapies to slow disease progression and enhance patient outcomes. Study Design A multidisciplinary team from Fondazione Policlinico Universitario Agostino Gemel…
This description comes directly from the study's public registry record.
Giuseppe La Rocca · + 39 3283776263 · giuseppe.larocca@policlinicogemelli.it
Gianluca Galieri · +39 3298803674 · gianluca.galieri01@icatt.it
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| Fondazione Policlinico Agostino Gemelli IRCSS | Rome, RM, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07026552