● Recruiting

Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally Recurrent PD-L1 Positive (CPS≥1) HNSCC

Condition: Recurrent Head and Neck Squamous Cell Carcinoma · Sponsor: Universität des Saarlandes

PhasePhase 3

Planned participants214

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

Prospective, open-label, randomized controlled phase III trail that aims to investigate whether Re-Radiochemotherapy (Re-RCT) and sequential immunotherapy with pembrolizumab improves overall survival compared to the standard treatment with pembrolizumab alone (± chemotherapy) in locoregionally recurrent PD-L1 positive (CPS≥1) HNSCC.

This description comes directly from the study's public registry record.

Talk to the study team

Studienzentrum der Klinik für Strahlentherapie und Radioonkologie · +49 6841 - 16 24688 · repair.radonk@uks.eu

Markus Hecht, Prof. Dr. med. · +49 6841 - 16 24606 · markus.hecht.clinicaltrials@uks.eu

Always discuss trial participation with your own doctor first.

Locations (21)

Klinikum Chemnitz gGmbH, Klinik für Radioonkologie	Chemnitz, Germany	Recruiting
Klinikum Darmstadt GmbH, Institut für Radioonkologie und Strahlentherapie	Darmstadt, Germany	Recruiting
Gemeinschaftspraxis Hämatologie-Onkologie Dresden	Dresden, Germany	Recruiting
Helios Klinikum Erfurt, Klinik für Strahlentherapie	Erfurt, Germany	Recruiting
Uniklinikum Erlangen, Strahlenklinik	Erlangen, Germany	Recruiting
Universitätsmedizin Frankfurt, Klinik für Strahlentherapie und Onkologie	Frankfurt am Main, Germany	Recruiting
UKGM Gießen, Klinik für Strahlentherapie	Giessen, Germany	Recruiting
Universitätsklinikum Hamburg-Eppendorf, Zentrum für Onkologie; II. Medizinische Klinik und Poliklinik	Hamburg, Germany	Recruiting
Medizinische Hochschule Hannover (MHH), Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation	Hanover, Germany	Recruiting
Marien Hospital Herne, Klinik für Strahlentherapie und Radio-Onkologie	Herne, Germany	Recruiting
Universitätsklinikum des Saarlandes, Klinik für Strahlentherapie und Radioonkologie	Homburg, Germany	Recruiting
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Klinik und Poliklinik für Radioonkologie der Strahlentherapie	Mainz, Germany	Recruiting

+ 9 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07026474