Condition: Placenta Previa · Placenta Accreta Spectrum · Antepartum Bleeding · Sponsor: The Third Affiliated Hospital of Guangzhou Medical University
Current clinical practice guidelines recommend planned cesarean delivery(CD) at 34-37 weeks of gestation in pregnant women with placenta previa and accreta. Preterm birth may lead to neonatal immaturity, while laterCD may increase the risk of severe hemorrhage and surgery complications. Retrospective studies have shown that indicated CD occurs in approximately1/3 of patients before 36 weeks, with the main trigger being antepartum hemorrhage. However, the risk of antepartum hemorrhage is lower after 36 weeks. Recent study showed that delivery shifted from 34-36 weeks to 37 weeks did not increase therisk of maternal intraoperative/postoperative hemorrhage and emergency CD. To further validate this, we propose to conduct a randomized controlled study comparing the effect of planned delivery management strategies at 37 0/7-37 6/7 weeks of gestation with those at 36 0/7-36 6/7 weekson maternal and fetal outcomes. The aim of this study is to explore whether planned delivery up to 37 weeks in pregnant women with placenta previa and accreta improves neonatal outcomes without increasing maternal obstetric risks.
This description comes directly from the study's public registry record.
Qingwen Nie · +86 15622149953 · nieqingwen@126.com
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| The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou, Guangdong, China | Recruiting |
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou, Henan, China | Not Yet Recruiting |
| West China Second University Hospital, Sichuan University | Chengdu, Sichuan, China | Not Yet Recruiting |
| Peking University Third Hospital | Beijing, China | Not Yet Recruiting |
| The First Affiliated Hospital of Chongqing Medical University | Chongqing, China | Not Yet Recruiting |
| Guangzhou Women and Children's Medical Center | Guangzhou, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07025954