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Study identifier: NCT07024706 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase 2 Study of Disease Risk Mutation-Guided Finite Acalabrutinib+Venetoclax for Relapsed CLL Post-1L Finite cBTKi+BCL2i ± Obinutuzumab

Condition: Chronic Lymphocytic Leukemia (CLL) · Small Lymphocytic Lymphoma (SLL)  ·  Sponsor: AstraZeneca

PhasePhase 2
Planned participants80
Who can joinAll sexes, 18 Years to 130 Years
Healthy volunteersNo

About this study

This study will evaluate the efficacy and safety of finite-duration acalabrutinib plus venetoclax therapy in patients with relapsed CLL or SLL, and have previously responded to first line (1L) cBTKi + BCL2i therapy (± obinutuzumab) and maintained a response for at least two years post-treatment.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (36)

Research SiteBoston, Massachusetts, United StatesRecruiting
Research SiteCharlotte, North Carolina, United StatesWithdrawn
Research SiteCharlotte, North Carolina, United StatesRecruiting
Research SiteDurham, North Carolina, United StatesRecruiting
Research SiteWinston-Salem, North Carolina, United StatesRecruiting
Research SiteHorn, AustriaRecruiting
Research SiteGoiânia, BrazilNot Yet Recruiting
Research SitePorto Alegre, BrazilNot Yet Recruiting
Research SitePorto Alegre, BrazilNot Yet Recruiting
Research SiteSão Paulo, BrazilNot Yet Recruiting
Research SiteSão Paulo, BrazilNot Yet Recruiting
Research SiteBrno, CzechiaNot Yet Recruiting

+ 24 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07024706