Condition: Acute Myeloid Leukemia · Recurrent Acute Myeloid Leukemia · Sponsor: Children's Oncology Group
This phase III trial compares the effect of xylitol dental wipes to dental wipes without xylitol for the reduction of bloodstream infection in children with acute myeloid leukemia (AML). Xylitol is a naturally occurring sugar compound found in fruits and vegetables. Xylitol has been shown to limit the growth of bacteria in the mouth, and to reduce cavities, plaque on the teeth, and inflammation of the gums. Treatment for AML includes chemotherapy. Patients receiving chemotherapy for AML have a risk of developing bloodstream infections. Bloodstream infections can make patients very sick, can contribute to delays in treatment, and can even cause death. In AML patients, bacteria or fungus (yeast) can sometimes enter the bloodstream from the mouth. Using xylitol dental wipes may help to reduce bloodstream infections in children being treated for AML.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Arkansas Children's Hospital | Little Rock, Arkansas, United States | Recruiting |
| Valley Children's Hospital | Madera, California, United States | Recruiting |
| Kaiser Permanente-Oakland | Oakland, California, United States | Recruiting |
| Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | Denver, Colorado, United States | Recruiting |
| Alfred I duPont Hospital for Children | Wilmington, Delaware, United States | Recruiting |
| Nemours Children's Clinic-Jacksonville | Jacksonville, Florida, United States | Recruiting |
| Nemours Children's Hospital | Orlando, Florida, United States | Recruiting |
| Nemours Children's Clinic - Pensacola | Pensacola, Florida, United States | Recruiting |
| Children's Healthcare of Atlanta - Arthur M Blank Hospital | Atlanta, Georgia, United States | Recruiting |
| Lurie Children's Hospital-Chicago | Chicago, Illinois, United States | Recruiting |
| University of Kentucky/Markey Cancer Center | Lexington, Kentucky, United States | Recruiting |
| Norton Children's Hospital | Louisville, Kentucky, United States | Recruiting |
+ 16 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07022678