Condition: Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients · Sponsor: Sohag University
Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease characterized by pathogenic autoantibodies production against nuclear structures . SLE affecting mainly women of childbearing age and is characterized by unpredictable flares and remissions. Disease severity varied from a mild episodic disorder to a rapidly progressive life-threatening illness. The kidney is the most commonly involved visceral organ in SLE. Therefore, identifying new noninvasive biomarkers of LN severity and outcome is mandatory. IL-17 is a potent pro-infammatory cytokine that amplifes T-cell activation and stimulates fibroblast cells, endothelial, and epithelial cells to produce several pro-infammatory mediators, including IL-1β, IL-6, and TNF-α. IL-17 receptor signaling enhances the expression of multiple pro-infammatory mediators. Hence, IL-17 enhances the production of neutrophil-attracting chemokines
This description comes directly from the study's public registry record.
Sara M Ahmed, resident · 01099676623 · sara_abdelrahim_post@med.sohag.edu.eg
abdelhady R Abdel-Gawad, MD · 01006955537
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| Sohag university Hospital | Sohag, Egypt | Recruiting |
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