Condition: Critical Illness Myopathy · Sponsor: University of Chile
The goal of this clinical trial is to study whether physical therapy can reduce NLRP3 inflammasome activation and muscle atrophy in patients with critical illness myopathy (CIM). It will also explore the role of NLRP3 inflammasome in the pathophysiology of CIM. The main questions this study aims to answer are: Is NLRP3 inflammasome activation associated with muscle atrophy through the upregulation of atrogenes? Does physical therapy attenuate NLRP3 inflammasome activation in skeletal muscle, thereby contributing to the prevention or reduction of muscle atrophy in CIM? Researchers will compare enhanced physical therapy using servo-assisted bed cycling (Motomed Letto®) in critically ill patients at risk of developing CIM during the early phase of ICU stay to conventional physical therapy (standard physiotherapy), to assess whether physical therapy reduces NLRP3 inflammasome activation and muscle degradation. Participants will: Be randomized to receive either conventional physical therapy or enhanced physical therapy (Motomed Letto®) for 7 consecutive days. A control group of patients without CIM will also be included. Undergo assessments of NLRP3 activity, muscle atrophy markers, and transcriptomic profiles from serum and vastus lateralis muscle biopsies. Be clinically evaluated using the SOFA scale and muscle ultrasound for CIM diagnosis. Be followed up for changes in muscle strength and physical functionality. Provide sociodemographic and clinical information to be …
This description comes directly from the study's public registry record.
Óscar L Arellano-Pérez, MSc. · +56961479414 · oscar.arellano@ug.uchile.cl
Paola A Llanos, PhD · +56997482044 · pllanos@odontologia.uchile.cl
Always discuss trial participation with your own doctor first.
| Clínica INDISA | Santiago, Metropolitan Region, Chile | Recruiting |
| Hospital de Urgencia Asistencia Pública (HUAP) | Santiago, Metropolitan Region, Chile | Recruiting |
| University of Chile | Santiago, Metropolitan Region, Chile | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07017517