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Study identifier: NCT07015905 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

Condition: Venous Thromboembolism (VTE)  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 3
Planned participants2000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (46)

Shoals Medical Trials, Inc.Sheffield, Alabama, United StatesRecruiting
CARI Clinical TrialsRiverside, California, United StatesRecruiting
Denver Metro Orthopedics, P.C. Englewood LocationEnglewood, Colorado, United StatesRecruiting
Delray Physician Care CenterDelray Beach, Florida, United StatesRecruiting
Bioresearch PartnerMiami, Florida, United StatesRecruiting
Sacred Heart Health System IncPensacola, Florida, United StatesRecruiting
Gulfcoast Research InstituteSarasota, Florida, United StatesRecruiting
Phoenix Clinical ResearchTamarac, Florida, United StatesRecruiting
Sinai Hospital of Baltimore, Inc.Baltimore, Maryland, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Curalta Clinical TrialsWestwood, New Jersey, United StatesRecruiting
Duke University Health System (Duke Health), Duke University HospitalDurham, North Carolina, United StatesRecruiting

+ 34 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07015905