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Study identifier: NCT07006727 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

Condition: Small Cell Lung Carcinoma · Large Cell Neuroendocrine Carcinoma of the Lung · Neuroendocrine Prostate Cancer  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 1
Planned participants116
Who can joinAll sexes, 18 Years to 100 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of \[225Ac\]Ac-ETN029 and the safety and imaging properties of \[111In\]In-ETN029 in patients aged ≥ 18 years with locally advanced or metastatic DLL3 positive cancers.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111  ·  novartis.email@novartis.com

Always discuss trial participation with your own doctor first.

Locations (7)

University Of IowaIowa City, Iowa, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Corewell Health William Beaum HospRoyal Oak, Michigan, United StatesRecruiting
Fred Hutchinson Cancer Research CenterSeattle, Washington, United StatesRecruiting
Novartis Investigative SiteMontreal, Quebec, CanadaRecruiting
Novartis Investigative SiteSeoul, Seoul, South KoreaRecruiting
Novartis Investigative SiteSeoul, South KoreaRecruiting

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Source record: clinicaltrials.gov/study/NCT07006727