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Study identifier: NCT07006675 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

Condition: Tibial Fractures · Pain  ·  Sponsor: Major Extremity Trauma Research Consortium

PhasePhase 3
Planned participants1000
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs. standard pain management plus up to 6 weeks of NSAIDs (Group 2) in the treatment of tibial shaft fractures.

This description comes directly from the study's public registry record.

Talk to the study team

Thomas Higgins, MD  ·  801-870-113  ·  thomas.higgins@hsc.utah.edu

Katherine Frey, PhD  ·  kparris1@jhu.edu

Always discuss trial participation with your own doctor first.

Locations (14)

Eskenazi HospitalIndianapolis, Indiana, United StatesRecruiting
Indiana University-MethodistIndianapolis, Indiana, United StatesRecruiting
University of Maryland R Adams Cowley Shock Trauma CenterBaltimore, Maryland, United StatesRecruiting
Harvard Medical CenterCambridge, Massachusetts, United StatesRecruiting
Hennepin HealthMinneapolis, Minnesota, United StatesRecruiting
University of MississippiJackson, Mississippi, United StatesRecruiting
The MetroHealth SystemCleveland, Ohio, United StatesRecruiting
Allegheny General HospitalPittsburgh, Pennsylvania, United StatesRecruiting
Vanderbilt Medical CenterNashville, Tennessee, United StatesRecruiting
University of Texas Health Science Center - HoustonHouston, Texas, United StatesRecruiting
University of UtahSalt Lake City, Utah, United StatesRecruiting
Inova Fairfax HospitalFalls Church, Virginia, United StatesRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07006675