Condition: Pulmonary Embolism · Sponsor: Sahlgrenska University Hospital
International guidelines recommend immediate reperfusion with systemic thrombolysis (ST) as first-line treatment in high-risk pulmonary embolism (PE). The therapy improves hemodynamics and overall survival but is also associated with a significant risk of severe bleeding. Catheter-directed intervention (CDI) is recommended as an alternative reperfusion therapy in high-risk PE when ST is contraindicated or has failed, as well as in patients who deteriorate or fail to improve during anticoagulation (AC) treatment. Despite lack of high-quality evidence and randomized studies between CDI and standard care, the use of CDI is spreading rapidly in high-risk PE and in less severe PE not fulfilling current treatment criteria.
This description comes directly from the study's public registry record.
Freyr Einarsson, MD · +46500 43 10 36 · freyr.einarsson@vgregion.se
Annika Odenstedt, coordinator · +46 343 53 94 · annika.odenstedt@vgregion.se
Always discuss trial participation with your own doctor first.
| Aarhus University Hospital | Aarhus, Denmark | Recruiting |
| Rigshospitalet | Copenhagen, Denmark | Recruiting |
| Odense University Hospital | Odense, Denmark | Recruiting |
| Sahlgrenska University Hospital | Gothenburg, Sweden | Recruiting |
| Linköping University Hospital | Linköping, Sweden | Recruiting |
| Sunderby Hospital | Luleå, Sweden | Recruiting |
| Skåne University Hospital | Lund, Sweden | Recruiting |
| Örebro University Hospital | Örebro, Sweden | Recruiting |
| Danderyd Hospital | Stockholm, Sweden | Recruiting |
| Karolinska University Hospital Huddinge | Stockholm, Sweden | Recruiting |
| Karolinska University Hospital Solna | Stockholm, Sweden | Recruiting |
| Södersjukhuset | Stockholm, Sweden | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07003646