Condition: Glioblastoma · Brain Tumor · Sponsor: Case Comprehensive Cancer Center
The purpose of this study is to evaluate whether treating glioblastoma patients with sitagliptin can improve immune response against the tumor by targeting specific immune cells called myeloid-derived suppressor cells (MDSCs) that suppress your body's natural immune response against cancer. Sitagliptin is an investigational drug for this condition that works by inhibiting an enzyme called dipeptidyl peptidase 4 (DPP-4), which MDSCs rely on to enter the brain and function. While sitagliptin is FDA-approved for diabetes treatment, its use in glioblastoma is investigational (experimental).
This description comes directly from the study's public registry record.
David Peereboom, MD · 1-866-223-8100 · TaussigResearch@ccf.org
Always discuss trial participation with your own doctor first.
| Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute | Cleveland, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07003542