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Study identifier: NCT07001878 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis

Condition: Psychosis · Cannabis Use  ·  Sponsor: Nova Scotia Health Authority

PhasePhase 4
Planned participants24
Who can joinAll sexes, 18 Years to 25 Years
Healthy volunteersNo

About this study

Canada reports some of the highest rates of cannabis use in our youth and young adult populations, among all the developed countries. Recent Health Canada surveys report that 27% of 16-19-year-olds and 32% of 20-24-year-olds have used cannabis in the past 30 days, with 16-24-year-olds showing the highest rates of daily or near-daily use. Unfortunately, cannabis use has also been found to be a risk factor for the development of a psychotic disorder in emerging adults, and in those who develop psychosis and continue cannabis use, there is a significant effect on long term outcomes. This includes the severity of symptoms, risks of relapse (being hospitalized) and not reaching a level of functioning that would be expected. Lifetime experience with cannabis is greater than 80% in young adults with early phase psychosis (EPP; the first 5 years of a psychosis illness) with up to 30% of Canadian EPP patients meeting criteria for a diagnosis of cannabis use disorder (CUD) at entry to care. A recent Canadian population-based study found that cannabis use disorder associated to psychosis has risen from 3.7% pre-2018 to 10.3% at present. There has been a significant increase in Δ9-tetrahydrocannabinol (THC) levels in cannabis products available globally over the years, with popular cannabis products available start as high as 18% THC in Canada. However high potency cannabis carries a more significant risk for psychosis development, as well as higher risk for cannabis dependence and other…

This description comes directly from the study's public registry record.

Talk to the study team

Rachel Church, MSc.OT  ·  902-473-7474  ·  rachel.church@nshealth.ca

Candice E Crocker, PhD  ·  902-473-3755  ·  candice.crocker@nshealth.ca

Always discuss trial participation with your own doctor first.

Locations (2)

Psychosis Intervention Early Recovery ProgramSt. John's, Newfoundland and Labrador, CanadaRecruiting
Nova Scotia Early Psychosis ProgramHalifax, Nova Scotia, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT07001878