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Study identifier: NCT07000357 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

Condition: Cardiovascular Disease  ·  Sponsor: AstraZeneca

PhasePhase 3
Planned participants15100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in patients with established ASCVD or at high risk for a first ASCVD event. The effect of AZD0780 vs placebo on the risk of MACE-PLUS will be evaluated from randomisation until the primary analysis censoring date (PACD). The Study Closure Visit will be scheduled to occur after the PACD and will be the final visit for each participant in the study.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (1365)

Research SiteAthens, Alabama, United StatesNot Yet Recruiting
Research SiteBirmingham, Alabama, United StatesRecruiting
Research SiteDothan, Alabama, United StatesNot Yet Recruiting
Research SiteFairhope, Alabama, United StatesRecruiting
Research SiteFoley, Alabama, United StatesRecruiting
Research SiteHuntsville, Alabama, United StatesWithdrawn
Research SiteMobile, Alabama, United StatesRecruiting
Research SiteMobile, Alabama, United StatesNot Yet Recruiting
Research SiteSaraland, Alabama, United StatesRecruiting
Research SiteVestavia Hills, Alabama, United StatesRecruiting
Research SiteGilbert, Arizona, United StatesRecruiting
Research SiteGlendale, Arizona, United StatesTerminated

+ 1353 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07000357